Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Injectable chemotherapeutic gels for the treatment of glioblastoma multiforme

Eduardo Ruiz-Hernandez, Department of Anatomy and School of Pharmacy. Keywords: cancer, bioengineering, pharmacy, pharmaceutical sciences & chemistry, drug delivery systems, injectable gels, glioblastoma.

Advanced nanotechnology-based materials offer new solutions to the challenges associated with the non-specific delivery of therapeutics that leads to ineffective treatments, especially in oncology. Currently, both therapeutic and diagnostic molecules are administered systemically, increasing the likelihood of unwanted side effects. We aim to develop a novel delivery system that enables selective, targeted local delivery of therapeutics and imaging agents. Specifically, we will use this delivery system to design a therapy for the treatment of glioblastoma multiforme, the most aggressive form of brain cancer. The system will comprise a unique combination of advanced injectable polymeric depots and targeted nanoparticles with both chemotherapeutic and imaging agent payloads (‘theranosticâ€TM nanoparticles). The polymeric depots will provide a continuous release of free chemotherapeutic drug, with a tunable profile depending on the polymer composition, and cancer-targeted nanoparticles that will release the theranostic cargo only after selective uptake by cancer cells. This project aims to advance the state-of-the-art in nanomedicines through advances to the individual components of the developed delivery system. This proposal represents a unique opportunity in the context of nanotheranostics for tailored chemotherapy, and means a significant step towards its clinical translation. This research is a collaboration between European research groups and industrial partners.

Mentors Eduardo Ruiz-Hernandez. eduardorhernandez@rcsi.ie