Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Novel peptidomimetics of Nature's antibiotics

Marc Devocelle, Pharmaceutical and Medicinal Chemistry. Keywords: Infection & Immunity, Peptidomimetics, Antimicrobial Peptides, Antibiotic resistance.

Peptides are one of the fastest growing classes of new drugs, with a growth rate which nearly doubles the growth rate for Active Pharmaceutical Ingredients overall. The clinical application of therapeutic peptides usually requires a technological solution addressing the limitations associated with their limited bioavailability and potential toxicity. The conversion of peptides into peptidomimetics is one of the main approaches developed to exploit their therapeutic potential.

The host laboratory has developed a novel approach to generate peptidomimetic candidates. This peptidomimetic transformation has been demonstrated with one class of peptides, generating candidates displaying performances approaching those of the best commercial reagents in this class. It is now proposed to apply this peptidomimetic conversion to Antimicrobial Peptides (AMP). AMPs, or Host Defence Peptides, have been coined as ‘Nature's antibiotics'. In the context of an announced public health crisis caused by the resistance of pathogenic bacteria against antibiotics, AMPs have been recognised as promising candidates for the generation of a novel class of antibiotics addressing effectively and durably this clinical problem. Opportunities exist to develop novel AMP mimetics which can be targeted against the pathogens listed in the top 6 organisms to which new antibiotics are urgently needed.

Mentors Marc Devocelle. mdevocelle@rcsi.ie, +353 1 4022176.