Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

PhD: Dr Marco Monopoli - Pharmaceutical and Medical Chemistry

Nanoparticles are believed to radically change the way we treat diseases. Because of their small size, they can directly interact with biomolecules in a completely different way and their behavior in biology is still not fully understood.

Project title: Understanding the role of the biomolecules at the BioNano interface

Nanoparticles are believed to radically change the way we treat diseases.

Because of their small size, they can directly interact with biomolecules in a completely different way and their behavior in biology is still not fully understood.

Once in biological fluids, nanoparticles rapidly interact with biomolecules from the environment that strongly and rapidly adsorb to the NP surface forming the long-lived biomolecular corona. [1, 2]

The biomolecular corona gives a new identity to nanoparticles in biological milieu as it has been shown to directly interact with cellular receptors while the pristine surface remains buried while in this environment.

This project is focused on understanding how these biomolecules control the biological fate of the nanomaterials in biological milieu and to explore new opportunities for new applications.

 

[1]. Monopoli et al. Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol. 2012 Dec;7(12):779-86.

[2]. Wan et al. The "sweet" side of the protein corona: effects of glycosylation on nanoparticle-cell interactions. ACS Nano. ACS Nano. 2015 Feb 24;9(2):2157-66.

Mentors Dr Marco Monopoli