Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

FUNDED PhD: Dr Oran Kennedy - Arthritis, Joint Disease, Mechanobiology

The project seeks to find a highly motivated student to investigate the role of subchondral bone in post-traumatic osteoarthritis (PTOA), which typically affects a younger population (often highly active, such as athletes) compared with age-related osteoarthritis. The successful candidate will be based in the Tissue Engineering Research Group at RCSI applying novel approaches to detect PTOA progression and investigating drug delivery systems that will mitigate joint degeneration.

Project title

The Role of Subchondral Bone in Post-Traumatic Osteoarthritis Following Joint Injury

Project description

Arthritis is a condition that is typically associated with advancing age – however a subset of the disease called Post-Traumatic Osteoarthritis (PTOA) affects a much younger population. PTOA develops following joint injury, such as ACL rupture of the knee, about 10 years after the initial event – but why this happens is unknown. What has become clear in recent years is that other joint tissues (in addition to cartilage) are involved.

The aim of this project is to use novel cell-culture and animal models to understand the role of subchondral bone in PTOA initiation and progression and to develop ways to target specific tissues with drug delivery systems that will mitigate joint degeneration. The student will be primarily based in the Tissue Engineering Research Group at RCSI and will work closely with other members of a multidisciplinary project team including PIs, postdoctoral and postgraduate researchers within this research cluster.

Title: PhD Student
Department: Anatomy
Tenure: Four years
Location: 123 St Stephen's Green
Reporting to: Dr Oran Kennedy
Salary: €18,000 per year
Deadline for application: Friday, 31 March 2017
 
Please complete the application form and go to the RCSI School of Postgraduate Studies Recruitment portal to apply for this scholarship.

Mentors Dr Oran Kennedy