Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

PhD: Dr Oran Kennedy - Bone-Cartilage Crosstalk in Post Traumatic Osteoarthritis after Acute Joint Injury

The aim of this PhD project is to develop novel cell-culture and animal models to understand the role of subchondral bone in PTOA initiation and progression.

Project description

Post-traumatic osteoarthritis (PTOA) is a subset of the broader condition of OA, and affects a much younger, more active (typically athletic) population. ACL rupture of the knee is a common injury that leads to PTOA 10-15 years after the initial event – but why this happens is unknown.

It is now clear that this complex trauma-induced pathology involves multiple joint tissues in addition to cartilage. The aim of this project is to develop novel cell-culture and animal models to understand the role of subchondral bone in PTOA initiation and progression and to develop ways to target specific tissues with drug delivery systems to mitigate joint degeneration.

The student will be primarily based in RCSI and will work closely with other members of a multidisciplinary project team including PIs, postdoctoral and postgraduate researchers within this research cluster.

  • Research theme: Bioengineering
  • Keyword: Post-Traumatic Osteoarthritis, bone/cartilage crosstalk, early intervention therapeutics

Application process

Interested candidates please contact Dr Oran Kennedy, Department of Anatomy, RCSI.

Mentors Dr Oran Kennedy