Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

PhD: Prof. Fergal O'Brien - Advanced scaffold-based therapeutics for regeneration of large volume, vascularised bone defects

The aim of this project is to develop novel functionalised collagen-based scaffolds for the delivery of nucleic acid-based therapeutics using novel nanoparticle formulations. These scaffolds will be used as platforms for the repair of large volume, vascularised bone defects.

Project title

Advanced scaffold-based therapeutics for regeneration of large volume, vascularised bone defects.

Project description

The researcher will be based in the Tissue Engineering Research Group and AMBER Centre at RCSI and will work closely with other members of a multidisciplinary project team including PIs, postdoctoral and postgraduate researchers.

The student will also work with a number of clinical and academic collaborators:

  • Prof. Heinz Redl - Ludwig Boltzmann Institute
  • Prof. Kevin Shakesheff and Dr James Dixon - University of Nottingham
  • Prof. Valeria Nicolosi - Trinity College Dublin, CRANN
  • Prof. Cathal Moran - Trinity College Dublin, Sports Surgery Clinic

  • Department: Anatomy
  • Theme: Bioengineering
  • Keywords: Gene-activated scaffolds, nanoparticles, bone repair

The candidate

  • The ideal applicant will have a 1st Class Honours Bachelor’s degree in biomedical engineering, pharmacy, or related disciplines and preferably, an MSc degree (with minimum 2.1 honours from primary degree) in regenerative medicine/drug delivery systems. 
  • Specific skills which would enhance a candidate’s application might include experience in some of the following areas: scaffold development in tissue engineering, drug/biomolecule delivery, nano-particle synthesis and fabrication, cell culture, and molecular biology experience. 
  • Excellent written and oral communication skills are essential.

Application process

Please apply by email to with:

  • An up-to-date CV
  • A 500-word cover letter outlining your interest in and suitability for the position
  • Scanned transcripts (preferred), or detailed degree grade breakdown
  • Contact details of two referees
  • Closing date: 31 October 2017

Mentors Prof. Fergal O'Brien