Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Available Research Projects

PhD: Prof. Fergal O'Brien - Advanced scaffold-based therapeutics for regeneration of large volume, vascularised bone defects

The aim of this project is to develop novel functionalised collagen-based scaffolds for the delivery of nucleic acid-based therapeutics using novel nanoparticle formulations. These scaffolds will be used as platforms for the repair of large volume, vascularised bone defects. More Information.


FUNDED PhD: Dr Finbarr Leacy - Biostatistics

The project seeks to find a highly motivated student to carry out a study focused on the evaluation of health policies in the Irish healthcare setting using state-of-the-art causal inference methods. The successful candidate will apply existing propensity score and instrumental variable approaches to nationally representative databases, cohort studies and disease registries; developing extensions of these approaches where necessary. More Information.


FUNDED PhD: Dr James O'Donnell - Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study

This research is part of the Irish Personalised Approach to the Treatment of Haemophilia (iPATH) study, based in the RCSI and St James’s Hospital, Dublin. More Information.


FUNDED PhD: Dr Darran O’Connor and Prof. Jochen Prehn - Cancer Systems Biology/Bioinformatics

The aim of this project is to develop a novel decision support tool for Her2+ breast cancer. More Information.


FUNDED PhD: Dr Marco Monopoli - Nanotechnology

The project seeks to find a highly-motivated student to carry out a study focused on obtaining a complete understanding of the mechanisms of interaction between nanomaterials and living systems essential for nanomedicine, nanotoxicology applications and to evaluate their environmental impact. More Information.


PhD: Dr Cathal Cadogan - Development of a theory-based intervention to improve long-term use of benzodiazepines and Z-drugs in primary care

The aim of this project is to develop a theory-based intervention to improve long-term use of benzodiazepines and Z-drugs in primary care. More Information.


PhD: Dr Fiona O’Brien - Medication safety in neonatal intensive care

This project will examine and determine flow characteristics for typical infusion setups currently used in the Neonatal Intensive Care Unit (NICU) of the Rotunda Hospital. More Information.


PhD: Dr Claire McCoy - Understanding the impact of microRNAs in Immunometabolism

This PhD project will specifically focus on understanding how microRNAs regulate the metabolism of innate immune cells such as macrophages, an area of emerging importance in the field of immunology. More Information.


PhD: Dr Claire McCoy - Exploring novel roles for microRNAs in Neuroinflammation

This PhD project will specifically focus on understanding how microRNAs regulate neuroinflammation and the neuron-immune axis in the pathogenesis of Multiple Sclerosis. More Information.


PhD: Dr Ingmar Schoen - Spatiotemporal coordination of platelet behaviour during thrombus formation

The aim of this PhD project is to better understand how platelet mechanics contribute to different stages of thrombus formation. More Information.


PhD: Prof Brian Harvey - Endocrine modulation of colon cancer progression and tumorigenesis

The aim of this project is to determine the molecular mechanisms underlying sexual dimorphism in colorectal cancer tumorigenesis and patient survival. More Information.


PhD: Prof. Fergal O'Brien - Dressing4scars

Dressing4scars aims to develop a '4D printing' approach to develop smart responsive skin dressings capable of changing properties while wound healing/skin repair is taking place. More Information.


PhD: Prof. Fergal O'Brien - Advanced scaffold based delivery system for nucleic acids through the incorporation of novel nanoparticles

The aim of this project is to develop novel collagen-based scaffolds functionalised for the delivery of RNA-based therapeutics using nanoparticles recently developed by researchers in the SFI-funded CÚRAM and AMBER centres. The scaffolds will be used as novel platforms for tissue regeneration, in vitro disease modelling, and to study drug development/delivery. More Information.


PhD: Prof. Fergal O'Brien - Development of advanced biomaterials for bone and cartilage regeneration

The aim of this project is to enhance the bone and cartilage-forming potential of materials developed by TERG/SurgaColl by using DNA or RNA, to control mesenchymal stem cell hypertrophy. More Information.


Four funded PhDs - FutureNeuro - Prof. David Henshall and Prof. Gianpiero Cavalleri

These PhD projects are an excellent opportunity to be involved in FutureNeuro - SFI Research Centre for neurological diseases. More Information.


PhD: Dr Zeibun Ramtoola - Development of targeted nanomedicines in the treatment of IBD

This project aims to investigate the potential therapeutic effectiveness of oral nanomedicines currently under development in RCSI. More Information.


PhD: Dr Brona Murphy - Improving Treatment Options for Glioblastoma Patients

The aim of this PhD is to investigate the therapeutic efficacy of CDK inhibitors for GBM patients. More Information.


PhD: Dr Darren Griffith - Combating Antibiotic Resistance with Novel Bismuth-Biomolecular Conjugates

During this project, candidates will develop bismuth conjugates, which possess (i) the antibacterial properties of bismuth and (ii) antimicrobial and targeting properties associated with specific biomolecules of interest and will overcome bacterial resistance. More Information.


PhD: Dr Oran Kennedy - Bone-Cartilage Crosstalk in Post Traumatic Osteoarthritis after Acute Joint Injury

The aim of this PhD project is to develop novel cell-culture and animal models to understand the role of subchondral bone in PTOA initiation and progression. More Information.


PhD: Dr Marco Monopoli - Biomarker Assay for Precision Medicine

Candidates are currently being sought for an IRC grant application submission for a PhD by research in Biomarker Assay Development. More Information.


MSc: Dr Declan Patton - Management of venous leg ulcers

Two candidates are currently being sought for submission of an IRC grant application for a Masters by research in the management of venous leg ulcers. More Information.


FUNDED PhD: Dr Oran Kennedy - Arthritis, Joint Disease, Mechanobiology

The project seeks to find a highly motivated student to investigate the role of subchondral bone in post-traumatic osteoarthritis (PTOA), which typically affects a younger population (often highly active, such as athletes) compared with age-related osteoarthritis. The successful candidate will be based in the Tissue Engineering Research Group at RCSI applying novel approaches to detect PTOA progression and investigating drug delivery systems that will mitigate joint degeneration. More Information.


PhD: Maria Morgan - Molecular & Cellular Therapeutics

This project will address the role of hydroxyapatite in M1/M2 macrophage differentiation and the potential biological consequences of hydroxyapatite-derived macrophages in exacerbating tumor progression. More Information.


PhD: Tracy Robson - Molecular & Cellular Therapeutics

This project brings together the expertise staff within Molecular & Cellular Therapeutics and collaborators within the pharmaceutical industry. More Information.


PhD: Dr Marco Monopoli - Pharmaceutical and Medical Chemistry

Nanoparticles are believed to radically change the way we treat diseases. Because of their small size, they can directly interact with biomolecules in a completely different way and their behavior in biology is still not fully understood. More Information.


Exosomes trigger tumour neovascularisation and and subsequent escape from chemotherapy

Olga Piskareva, Molecular & Cellular Therapeutics. Keywords: cancer, neuroscience, drug resistance, angiogenesis, exosomes. More Information.


Network meta analysis of psychological factors influencing health behaviours

Frank Doyle, Psychology. Keywords: cancer, cardiovascular disorders, respiratory diseases, population health, gynaecology, obstetrics & perinatal health, network meta-analysis, health behaviours, psychological factors. More Information.


Depression and health behaviours in chronic conditions

Frank Doyle, Psychology. Keywords: cardiovascular disorders, respiratory diseases, population health, depression, behaviour change, adherence. More Information.


Adherence to inhaled therapies

Frank Doyle, Psychology. Keywords: respiratory diseases, inhaled therapy, adherence, behaviour change. More Information.


Psychometrics of patient reported outcomes

Frank Doyle, Psychology. Keywords: population health, patient reported outcomes, item response theory, psychometrics. More Information.


Provision of smoking cessation care in hospital settings

Frank Doyle, Psychology. Keywords: cancer, cardiovascular disorders, respiratory diseases, population health, medical education, smoking, behaviour change, medical education. More Information.


Attitudes to organ donation

Frank Doyle, Psychology. Keywords: population health, organ donation, attitudes, intervention. More Information.


Breast cancer microcalcification-induced local inflammation; potential consequences for tumour progression

Maria Morgan, Molecular & Cellular Therapeutics. Keywords: cancer, breast cancer, cell biology, immunology. More Information.


Automated flow micro-reactors and parallel microwave-assisted synthesis

Donal O'Shea, Pharmaceutical & Medicinal Chemistry. Keywords: pharmacy, pharmaceutical sciences & chemistry. More Information.


Mixed Li/K amides and enantioselective carbolithiations as effective synthetic tools

Donal O'Shea, Pharmaceutical & Medicinal Chemistry. Keywords: pharmacy, pharmaceutical sciences & chemistry. More Information.


New class of light activated anti-cancer and anti-microbial agents

Donal O'Shea, Pharmaceutical & Medicinal Chemistry. Keywords: cancer, pharmacy, pharmaceutical sciences & chemistry, photodynamic therapy (pdt), anti-cancer, anti-microbial. More Information.


New class of near-infrared (NIR) fluorochrome for real-time fluorescence guided surgery

Donal O'Shea, Pharmaceutical & Medicinal Chemistry. Keywords: pharmacy, pharmaceutical sciences & chemistry, nir fluorochrome, fluorochrome imaging, cancer. More Information.


Injectable chemotherapeutic gels for the treatment of glioblastoma multiforme

Eduardo Ruiz-Hernandez, Department of Anatomy and School of Pharmacy. Keywords: cancer, bioengineering, pharmacy, pharmaceutical sciences & chemistry, drug delivery systems, injectable gels, glioblastoma. More Information.


The Role of Platelets in Human Pregnancy: An exploration of the nature of the cytokine secretion profile during normal human pregnancy

Niamh Moran, Molecular & Cellular Therapeutics. Keywords: gynaecology, obstetrics & perinatal health, pregnancy, platelet, non-thrombotic. More Information.


Movement analysis of sports-related hip and groin pain

Helen French, School of Physiotherapy. Keywords: physiotherapy, 3D motion analysis, hip pain, movement screening. More Information.


The Role of Platelets in Cancer: An exploration of the nature of the cytokine secretion profile in during cancer progression

Niamh Moran, Molecular & Cellular Therapeutics. Keywords: cancer, cardiovascular disorders, platelet, metastasis More Information.


Novel peptidomimetics of Nature's antibiotics

Marc Devocelle, Pharmaceutical and Medicinal Chemistry. Keywords: Infection & Immunity, Peptidomimetics, Antimicrobial Peptides, Antibiotic resistance. More Information.


Nanomedicines against multi-drug resistant bacteria

Marc Devocelle, Pharmaceutical and Medicinal Chemistry. Keywords: Infection & Immunity, Antibiotic resistance, Antimicrobial Peptides, Prodrugs and nanomedicines. More Information.