Royal College of Surgeons in Ireland Coláiste Ríoga na Máinleá in Éirinn

Advanced Biomaterials, Stem Cells and Therapeutic Delivery

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RCSI research in the field of regenerative medicine focuses on the development of advanced biomaterials for tissue repair with applications in bone, cartilage, cardiovascular, respiratory, neural and corneal regeneration. These biomaterials are increasingly being used as therapeutic bioactive platforms for the delivery of stem cells & growth factors or as gene-activated matrices to promote enhanced tissue repair.

In the drug delivery field, RCSI has also expertise in pre-formulation, drug analysis, formulation and development of drug delivery platforms. We develop micro- and nanoparticulate drug delivery systems, nanotechnologies, lipid based delivery systems, bioresponsive drug deliver platforms and non-viral gene delivery vectors, nanoparticles for solubility and permeability enhancement and siRNAs.

RCSI expertise in the development of therapeutics includes synthesis of metal complexes, light activated anti-cancer and anti-microbial agents, design and preparation of natural and unnatural RNA-binders and their targeted delivery

RCSI research in regenerative medicine, advanced biomaterials and drug delivery plays a leading role in a number of large collaborative research networks/programmes, involving partners from industry, academia and clinical organisations. These include AMBER, CURAM, the Trinity Centre for Bioengineering and major EU funding initiatives.

Senior Academics/Researchers and Research Centres and Programmes in this area are listed below:

PIDepartmentProfile
Fergal O'Brien Anatomy View Fergal O'Brien's profile
Garry Duffy Anatomy View Garry Duffy's profile
Donal O’Shea Medicinal chemistry View Donal O'Shea's profile
Mauro Adamo Medicinal chemistry View Mauro Adamo's profile
Sally-Ann Cryan  Pharmacy View Sally-Ann Cryan's profile
Helena Kelly   Pharmacy  View Helena Kelly's profile
Celine Marmion Medicinal chemistry View Celine Marmion's profile
Marc Devocelle  Medicinal chemistry View Marc Devocelle's profile 

Research Centres & Programmes in this Area

AMBER - Advanced Materials and BioEngineering Research 

Science Foundation Ireland (SFI)-funded AMBER Centre, provides a partnership between leading researchers in material science and industry, bringing together leading international research centres in bioengineering and nanotechnology, the Trinity Centre for Bioengineering (TCBE) and Centre for Research on Adaptive Nanostructures and Nanodevices (CRANN) in addition to the Tissue Engineering Research Group based at RCSI, as well as researchers in materials chemistry from UCC. The aim of the centre is to deliver internationally leading materials research that will be industrially and clinically informed with outputs including new discoveries and devices. AMBER has an exceptionally strong emphasis on linking industry to research programmes and its goal is to become an internationally recognised centre of excellence for materials - based in Ireland.

AMCARE - Advanced Materials for Cardiac Regeneration 

AMCARE is a translational research program to develop advanced multimodal regenerative therapies using cardiopoeitic stem cells and smart biomaterials that effectively treat damage caused by acute myocardial infarction (MI). This project has received funding from the European Union's Seventh Framework Programme for research, technological development and demonstration.

CÚRAM - Centre for Research in Medical Devices - Galway


SFI Research Centre CÚRAM, is to radically improve health outcomes for patients by developing innovative implantable medical devices, to respond to the body's environment and to deliver therapeutic agents, such as drugs, exactly where needed. CÚRAM's outputs will particularly benefit patients with chronic diseases such as heart disease, diabetes and musculoskeletal diseases. Devices will be developed with strong clinical collaborations, with industry partners and hospital groups, to enable rapid translation to the clinic.

IDDN Irish Drug Delivery Research Network 

The cluster includes RCSI with partner TCD, UCD, UCC, funded by SFI under the Strategic Research Cluster Scheme and provides research solutions for academia and industry in the field of drug delivery.